News | Longevity Science
Science Spotlight | August
Upsana Tayal MD |Sanjay Prasad MD FACS | Stuart Cook PhD
Identifying rare and common genetic variants contributing to systolic heart failure has been challenging given given its diverse and multiple etiologies. DCM, however although rarer,is a reasonably specific and well defined condition, leading to identification of many rare genetic variants.
Metabolic biomarkers and gallstone disease - a population-based study.
D. Shabanzadeh, T. Skaaby, L. Sørensen, J. Eugen-Olsen & T. Jørgensen
News | Epidemiology
Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis.
eGFR and Albuminuria in Relation to Risk of Incident Atrial Fibrillation: A Meta-Analysis of the Jackson Heart Study,
News | Genomics
Genetics Investigation into the Differential Risk of Atrial Fibrillation Among Black and White Individuals
Jason D. Roberts MD MAS Donglei Hu PhD et al
The rs10824026 SNP on chromosome 10q22 mediates a modest proportion of the increased risk of AF among white individuals compared with black individuals, potentially through an effect on gene expression levels of MYOZ1.
Extracting Research-Quality Phenotypes from Electronic Health Records to Support Precision Medicine
Wei-Qi Wei MD PhD | Joshua Denny MD MS
The convergence of two rapidly developing technologies - high-throughput genotyping and electronic health records (EHRs) - gives scientists an unprecedented opportunity to utilize routine healthcare data to accelerate genomic discovery.
Anti-PCSK9 Vaccine Lowers Cholesterol and Atherosclerosis in Mice
AT04A vaccine induces an effective immune response against PCSK9 in APOE*3Leiden.CETP mice, leading to a significant reduction of plasma lipids, systemic and vascular inflammation, and atherosclerotic lesions in the aorta. AT04A vaccine induces an effective immune response against PCSK9 in APOE*3Leiden.CETP mice, leading to a significant reduction of plasma lipids, systemic and vascular inflammation, and atherosclerotic lesions in the aorta.
Cardiac Examination: Stethoscope or Pocket Echo—Why Not Both?
The pocket echo examination can be performed at the point of care, at the bedside or in the clinic. The pocket echo can accurately provide data regarding left ventricular (LV) function (LV ejection fraction, LV enlargement, LV hypertrophy, cardiomegaly) that the cardiologist can only infer by the patient’s signs and symptoms.
Cardiac Stem Cells Found To Help Reverse Signs Of Aging When Injected Into Rats’ Hearts.
Cardiac stem cells derived from young hearts helped reverse the signs of aging when directly injected into the old hearts of elderly rats. The animals could exercise further than they could before by about 20%. In addition, The rats that received cardiosphere-derived cells experienced improved heart function and longer heart cell telomeres.
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